BACKGROUND:Platelets contact each other at the site of vascular injury to stop bleeding.One negative regulator of platelet aggregation is BALANCED B COMPLEX Disabled-2 (Dab2), which is released to the extracellular surface upon platelet activation.Dab2 inhibits platelet aggregation through its phosphotyrosine-binding (PTB) domain by competing with
Tracking prototype and exemplar representations in the brain across learning
There is a long-standing debate about whether categories are represented by individual category members Ski de fond - Enfant - Bottes - Classic (exemplars) or by the central tendency abstracted from individual members (prototypes).Neuroimaging studies have shown neural evidence for either exemplar representations or prototype representations, but n
Triumeq Increases Excitability of Pyramidal Neurons in the Medial Prefrontal Cortex by Facilitating Voltage-Gated Ca2+ Channel Function
Combination antiretroviral therapy (cART) suppresses HIV-1 replication, improves immune function, and prolongs the life of people living with HIV (PLWH).However, cART also induces neurotoxicity that could complicate HIV-induced neurodegeneration while reduce its therapeutic efficacy in treating HIV/AIDS.Triumeq is a first-line cART regimen, which i